PLAGL1 Antibody (PACO01713)
- SKU:
- PACO01713
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PLAGL1 Antibody (PACO01713)
The Plagl1 Polyclonal Antibody (PACO01713) is a valuable tool for research involving the Plagl1 protein, which is known for its role in regulating cell growth and differentiation. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the Plagl1 protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for studies in cancer biology and developmental biology.Plagl1, also known as pleiomorphic adenoma gene-like 1, is a transcription factor that plays a key role in controlling gene expression and cell proliferation.
Dysregulation of Plagl1 has been implicated in various cancers and developmental disorders, making it a promising target for research into disease mechanisms and potential therapeutic interventions. Understanding the function of Plagl1 is essential for uncovering its involvement in cancer progression and identifying novel treatment strategies.
| Antibody Name: | PLAGL1 Antibody |
| Antibody SKU: | PACO01713 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the Internal region of human ZAC1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PLAGL1; LOT1; ZAC; Zinc finger protein PLAGL1; Lost on transformation 1; LOT-1; Pleiomorphic adenoma-like protein 1; Tumor supressor ZAC |
| UniProt Protein Function: | PLAGL1: Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 6q24-q25 Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm; nucleus Molecular Function:DNA binding Biological Process: apoptosis; cell cycle arrest; cell differentiation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of transcription from RNA polymerase II promoter Disease: Diabetes Mellitus, Transient Neonatal, 1 |
| NCBI Summary: | This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q9UM63 |
| NCBI GenInfo Identifier: | 158523334 |
| NCBI Gene ID: | 5325 |
| NCBI Accession: | Q9UM63.2 |
| UniProt Secondary Accession: | Q9UM63,O76019, Q7Z3V8, Q92981, Q96JR9, Q9UIZ0, B2RBA4 B2RCM8, E1P595, E1P597, |
| UniProt Related Accession: | Q9UM63 |
| Molecular Weight: | 44,668 Da |
| NCBI Full Name: | Zinc finger protein PLAGL1 |
| NCBI Synonym Full Names: | PLAG1 like zinc finger 1 |
| NCBI Official Symbol: | PLAGL1Â Â |
| NCBI Official Synonym Symbols: | ZAC; LOT1; ZAC1Â Â |
| NCBI Protein Information: | zinc finger protein PLAGL1 |
| UniProt Protein Name: | Zinc finger protein PLAGL1 |
| UniProt Synonym Protein Names: | Lost on transformation 1; LOT-1; Pleiomorphic adenoma-like protein 1; Tumor suppressor ZAC |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | PLAGL1Â Â |
| UniProt Entry Name: | PLAL1_HUMAN |
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