The PLA2R1 Monoclonal Antibody is a powerful tool for researchers studying the PLA2R1 protein, a key player in autoimmune diseases such as membranous nephropathy. This monoclonal antibody, produced through hybridoma technology, exhibits high specificity and sensitivity in detecting PLA2R1 in human samples. Validated for use in various applications including immunohistochemistry and ELISA, this antibody allows for precise and reliable detection of PLA2R1 in tissue samples, making it an invaluable asset for studies in nephrology and autoimmune disease research.PLA2R1, a receptor for secretory phospholipase A2, is a crucial component in the pathogenesis of membranous nephropathy, an autoimmune kidney disease characterized by the deposition of autoantibodies against PLA2R1 in the glomerular basement membrane.
By targeting and studying the expression of PLA2R1, researchers can gain insights into the mechanisms underlying autoimmune kidney disorders and develop potential therapeutic strategies for their treatment. The PLA2R1 Monoclonal Antibody offers a reliable tool for investigating the role of PLA2R1 in disease pathology and developing targeted interventions to improve patient outcomes.
Product Name:
PLA2R1 Monoclonal Antibody
SKU:
CAB23148
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant protein of human PLA2R1.
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
PLA2R; PLA2-R; PLA2IR; CLEC13C; PLA2G1R; PLA2R1
Positive Sample:
HeLa,Mouse brain,Rat liver
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
169kDa
Observed MW:
182kDa
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
22925
Clone Number:
ARC59749
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PLA2R1 antibody (CAB23148) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
