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Pla2g5 Antibody (PACO28978)

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SKU:
PACO28978
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€359

Description

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Pla2g5 Antibody (PACO28978)

The PLA2G5 Polyclonal Antibody (PAC028978) is a valuable tool for researchers studying PLA2G5, a secretory phospholipase enzyme involved in lipid metabolism and inflammatory pathways. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it suitable for use in various applications such as Western blotting.PLA2G5, also known as group V phospholipase A2, plays a crucial role in the hydrolysis of phospholipids, releasing fatty acids and lysophospholipids which are important signaling molecules in inflammation and immunity.

Dysregulation of PLA2G5 activity has been implicated in various diseases including cancer, cardiovascular disorders, and neuroinflammatory conditions. By targeting PLA2G5, researchers can gain insights into the role of this enzyme in disease pathogenesis and develop potential therapeutic interventions targeting lipid metabolism and inflammation.

Antibody Name:Pla2g5 Antibody (PACO28978)
Antibody SKU:PACO28978
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse Calcium-dependent phospholipase A2 protein (21-137AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes L-alpha-palmitoyl-2-oleoyl phosphatidylcholine more efficiently than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol (By similarity).
Synonyms:Calcium-dependent phospholipase A2 (EC 3.1.1.4) (Group V phospholipase A2) (PLA2-10) (Phosphatidylcholine 2-acylhydrolase 5), Pla2g5
UniProt Protein Function:PLA2G5: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L- alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L- alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle. Defects in PLA2G5 are the cause of fleck retina, familial benign (FRFB). An autosomal recessive condition associated with a distinctive retinal appearance and no apparent visual or electrophysiologic deficits. Affected individuals are asymptomatic, but fundus examination reveals a striking pattern of diffuse, yellow-white, fleck-like lesions extending to the far periphery of the retina but sparing the foveal region. Belongs to the phospholipase A2 family.Protein type: Cell surface; EC 3.1.1.4; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 4 D3|4 70.57 cMCellular Component: cell surface; Golgi apparatus; perinuclear region of cytoplasm; plasma membraneMolecular Function: calcium-dependent phospholipase A2 activity; heparin binding; phospholipase A2 activity; receptor bindingBiological Process: arachidonic acid secretion; leukotriene biosynthetic process; negative regulation of inflammatory response; phospholipid metabolic process; platelet activating factor biosynthetic process; regulation of macrophage activation
UniProt Protein Details:
NCBI Summary:
UniProt Code:P97391
NCBI GenInfo Identifier:171906563
NCBI Gene ID:18784
NCBI Accession:NP_001116426.1
UniProt Secondary Accession:P97391,Q9QZU6
UniProt Related Accession:P97391
Molecular Weight:29.8kD
NCBI Full Name:calcium-dependent phospholipase A2
NCBI Synonym Full Names:phospholipase A2, group V
NCBI Official Symbol:Pla2g5  
NCBI Official Synonym Symbols:PLA2; sPLA2  
NCBI Protein Information:calcium-dependent phospholipase A2
UniProt Protein Name:Calcium-dependent phospholipase A2
UniProt Synonym Protein Names:Group V phospholipase A2; PLA2-10; Phosphatidylcholine 2-acylhydrolase 5
Protein Family:Calcium-dependent phospholipase
UniProt Gene Name:Pla2g5  
UniProt Entry Name:

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