The PLA2G4F Polyclonal Antibody (PAC011281) is a valuable tool for researchers studying PLA2G4F, an enzyme involved in the metabolism of membrane phospholipids and the regulation of inflammation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the PLA2G4F protein, this antibody enables the detection and analysis of PLA2G4F in various cell types, making it an essential tool for studies in immunology, inflammation, and lipid metabolism research.
PLA2G4F, also known as cytosolic phospholipase A2 gamma, plays a crucial role in the production of lipid mediators that regulate immune responses and inflammatory processes. Understanding the function of PLA2G4F is essential for deciphering its involvement in diseases such as cancer, cardiovascular disorders, and neuroinflammatory conditions. By targeting PLA2G4F, researchers can develop novel therapies that modulate lipid signaling pathways and inflammation, potentially leading to new treatment options for a range of inflammatory diseases.
phospholipase A2, group IVF;PLA2G4F;DKFZp666G192;DKFZp781B229;PLA2G4F/Z ;cPLA2-zeta
UniProt Protein Function:
PLA2G4F: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine. Has a much higher lysophospholipase and PLA(2) activity than PLA2G4B. Potently inhibited by pyrrolidine-2 and Wyeth-1. Its specific activity, inhibitor sensitivity, and low micromolar calcium dependence are similar to PLA2G4A. Translocates to ruffles and dynamic vesicular structures in a calcium-dependent manner. The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca2+ Three isoforms of the human protein are produced by alternative splicing.Protein type: Lipid Metabolism - arachidonic acid; EC 3.1.1.4; PhospholipaseChromosomal Location of Human Ortholog: 15q15.1Cellular Component: cytosolMolecular Function: lysophospholipase activity; phospholipase A1 activity; phospholipase A2 activityBiological Process: phospholipid metabolic process
