The PLA2G4E Polyclonal Antibody (PACO11280) is a valuable tool for researchers studying the PLA2G4E enzyme, which plays a crucial role in the inflammatory response and lipid metabolism. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications.PLA2G4E, also known as calcium-dependent phospholipase A2, is involved in the release of arachidonic acid from membranes, ultimately leading to the production of eicosanoids, inflammatory mediators that play a key role in immune response regulation. Research on PLA2G4E is important for understanding its role in inflammation, lipid signaling, and diseases such as cancer, cardiovascular disorders, and inflammatory conditions.
By using the PACO11280 Polyclonal Antibody, researchers can specifically detect and analyze PLA2G4E protein levels in various cell types, allowing for detailed investigation into its function and potential as a therapeutic target. Studies utilizing this antibody can provide insights into the complex mechanisms underlying inflammation and lipid metabolism, leading to the development of novel treatment strategies for a range of diseases.
phospholipase A2, group IVE;PLA2G4E;FLJ45651;MGC126633;MGC126661 ;
UniProt Protein Function:
PLA2G4E: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes glycerophospholipids in the sn-2 position. Translocates to lysosomal membranes in a calcium-dependent fashion. The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Two isoforms of the human protein are produced by alternative splicing.Protein type: Lipid Metabolism - alpha-linolenic acid; Phospholipase; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; EC 3.1.1.4Chromosomal Location of Human Ortholog: 15q15.1Cellular Component: lysosomal membrane; cytosolMolecular Function: phospholipase A2 activity; metal ion bindingBiological Process: phospholipid catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process
