The PLA2G4E Polyclonal Antibody (PACO03424) is a valuable tool for researchers studying PLA2G4E, an enzyme involved in the regulation of inflammation and lipid metabolism. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the PLA2G4E protein, allowing for precise detection and analysis in various cell types.PLA2G4E, also known as cytosolic phospholipase A2 epsilon, is a key player in the arachidonic acid pathway and plays a crucial role in mediating inflammatory responses. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and neuroinflammatory disorders.
By studying the function of PLA2G4E, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.Overall, the PACO03424 antibody offers a reliable and specific tool for investigating the role of PLA2G4E in health and disease. Its use in research can greatly contribute to our understanding of inflammation and lipid metabolism, with implications for the development of novel treatments in various pathological conditions.
Antibody Name:
PLA2G4E Antibody
Antibody SKU:
PACO03424
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human cPLA2-epsilon.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
PLA2G4E; Cytosolic phospholipase A2 epsilon; cPLA2-epsilon; Phospholipase A2 group IVE
UniProt Protein Function:
PLA2G4E: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes glycerophospholipids in the sn-2 position. Translocates to lysosomal membranes in a calcium-dependent fashion. The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Two isoforms of the human protein are produced by alternative splicing.Protein type: Lipid Metabolism - alpha-linolenic acid; Phospholipase; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; EC 3.1.1.4Chromosomal Location of Human Ortholog: 15q15.1Cellular Component: lysosomal membrane; cytosolMolecular Function: phospholipase A2 activity; metal ion bindingBiological Process: phospholipid catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process
