PLA2G4A Rabbit Polyclonal Antibody (CAB0394)
- SKU:
- CAB0394
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | PLA2G4A Rabbit Polyclonal Antibody |
SKU: | CAB0394 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-749 of human PLA2G4A (NP_077734.1). |
Sequence: | SGLT FNLP YPLI LRPQ RGVD LIIS FDFS ARPS DSSP PFKE LLLA EKWA KMNK LPFP KIDP YVFD REGL KECY VFKP KNPD MEKD CPTI IHFV LANI NFRK YKAP GVPR ETEE EKEI ADFD IFDD PESP FSTF NFQY PNQA FKRL HDLM HFNT LNNI DVIK EAMV ESIE YRRQ NPSR CSVS LSNV EARR FFNK EFLS KPKA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | GURDP; cPLA2; PLA2G4; cPLA2-alpha; PLA2G4A |
Positive Sample: | THP-1,NCI-H460,HT-29,HepG2,Mouse liver,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasmic vesicle. |
Calculated MW: | 85kDa |
Observed MW: | 115kDa |
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 5321 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |