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Pla2g2a Antibody (PACO34222)

SKU:
PACO34222
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407
Frequently bought together:

Description

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Pla2g2a Antibody (PACO34222)

The PLA2G2A Polyclonal Antibody (PACO34222) is a valuable tool for researchers studying PLA2G2A, an enzyme involved in lipid metabolism and inflammation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding specifically to the PLA2G2A protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in lipid metabolism, inflammation, and related fields.PLA2G2A, also known as phospholipase A2 group IIA, plays a crucial role in the hydrolysis of phospholipids, ultimately leading to the production of lipid mediators involved in inflammation and immune responses.

Given its involvement in these processes, PLA2G2A is a key player in various diseases, including inflammatory disorders, cardiovascular diseases, and cancer. By elucidating the functions and regulation of PLA2G2A, researchers can gain insights into disease mechanisms and potentially discover novel therapeutic targets for these conditions.

Antibody Name:Pla2g2a Antibody (PACO34222)
Antibody SKU:PACO34222
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Rat
Immunogen:Recombinant Rat Phospholipase A2, membrane associated protein (22-146AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Synonyms:Phospholipase A2, membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 2A), Pla2g2a
UniProt Protein Function:Function: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
UniProt Protein Details:

Catalytic activity: Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

Cofactor: Binds 1 calcium ion per subunit

By similarity.

Subcellular location: Membrane; Peripheral membrane protein.

Miscellaneous: Group II phospholipase A2 is found in many cells and also extracellularly. The membrane-bound and secreted forms are identical and are encoded by a single gene.

Sequence similarities: Belongs to the phospholipase A2 family.

NCBI Summary:hydrolyzes acyl group at the sn-2 position of phospholipids, forming non-esterified fatty acids and lysophospholipids; plays a critical role in inflammation; induces proliferation of smooth muscle cells [RGD, Feb 2006]
UniProt Code:P14423
NCBI GenInfo Identifier:291621686
NCBI Gene ID:29692
NCBI Accession:NP_113786.3
UniProt Related Accession:P14423
Molecular Weight:16,294 Da
NCBI Full Name:phospholipase A2, membrane associated
NCBI Synonym Full Names:phospholipase A2, group IIA (platelets, synovial fluid)
NCBI Official Symbol:Pla2g2a  
NCBI Official Synonym Symbols:sPLA2  
NCBI Protein Information:phospholipase A2, membrane associated; GIIC sPLA2; platelet phospholipase A2; group IIA phospholipase A2; eted enzyme type IIA phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A
UniProt Protein Name:Phospholipase A2, membrane associated
UniProt Synonym Protein Names:GIIC sPLA2; Group IIA phospholipase A2; Phosphatidylcholine 2-acylhydrolase 2A
Protein Family:Phospholipase
UniProt Gene Name:Pla2g2a  
UniProt Entry Name:PA2GA_RAT

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