The PLA1A Polyclonal Antibody (PACO22502) is a specialized tool for researchers studying the PLA1A enzyme, which is involved in lipid metabolism and inflammation. This antibody is produced in rabbits and has high specificity for detecting PLA1A in human samples. Validated for use in Western blot applications, this antibody binds to the PLA1A protein, allowing for precise detection and analysis in various cell types.PLA1A, an enzyme in the phospholipase A1 family, plays a key role in lipid remodeling and the regulation of inflammatory responses. Its involvement in lipid metabolism and inflammation makes it a promising target for research in areas such as metabolic disorders, cardiovascular disease, and inflammatory conditions.
Understanding the function of PLA1A is essential for developing potential therapies targeting lipid metabolism and inflammation-related diseases.Overall, the PACO22502 PLA1A Polyclonal Antibody is a valuable tool for researchers investigating the role of PLA1A in various biological processes, providing insights into potential therapeutic targets for conditions related to lipid metabolism and inflammation.
Antibody Name:
PLA1A Antibody (PACO22502)
Antibody SKU:
PACO22502
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human PLA1A.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human brain tissue using PLA1A antibody.
Background:
The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.
Synonyms:
Phospholipase A1 member A; EC 3.1.1.-; Phosphatidylserine-specific phospholipase A1; PS-PLA1;
UniProt Protein Function:
PLA1A: Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. Belongs to the AB hydrolase superfamily. Lipase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Secreted, signal peptide; EC 3.1.1.-; Secreted; Phospholipase
Chromosomal Location of Human Ortholog: 3q13.13-q13.2
The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
