PKP2 Rabbit Polyclonal Antibody (CAB5507)
- SKU:
- CAB5507
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PKP2 Rabbit Polyclonal Antibody |
SKU: | CAB5507 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 578-837 of human PKP2 (NP_001005242.2). |
Sequence: | LPEK YSQN IYIQ NRNI QTDN NKSI GCFG SRSR KVKE QYQD VPMP EEKS NPKG VEWL WHSI VIRM YLSL IAKS VRNY TQEA SLGA LQNL TAGS GPMP TSVA QTVV QKES GLQH TRKM LHVG DPSV KKTA ISLL RNLS RNLS LQNE IAKE TLPD LVSI IPDT VPST DLLI ETTA SACY TLNN IIQN SYQN ARDL LNTG GIQK IMAI SAGD AYAS NKAS KAAS VLLY SLWA HTEL HHAY KKAQ FKKT DFVN SRTA KAYH SLKD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ARVD9; PKP2 |
Positive Sample: | Raji,Mouse kidney,Mouse liver,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Nucleus, desmosome. |
Calculated MW: | 97kDa |
Observed MW: | 95-105kDa |
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. Mutations in this gene are associated with different inherited cardiac conditions including Arrythmogenic Cardiomyopathy, Brugada Syndrome, and Idiopathic Ventricular Fibrillation. A processed pseudogene with high similarity to this gene has been mapped to chromosome 12p13.
Purification Method: | Affinity purification |
Gene ID: | 5318 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |