The PKNOX2 Polyclonal Antibody (PACO1364) is a valuable tool for researchers studying PKNOX2, a transcription factor involved in cellular development and differentiation. This antibody, generated in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. It binds specifically to the PKNOX2 protein, allowing for precise detection and analysis in various cell types, making it ideal for research in developmental biology and cancer studies.PKNOX2, also known as Pre-B-cell leukemia homeobox 2, plays a crucial role in regulating gene expression and cell fate determination during embryonic development.
Its involvement in cellular processes makes it a key target for investigations into diseases such as cancer, developmental disorders, and neurodegenerative conditions. Understanding the function of PKNOX2 is essential for uncovering new therapeutic strategies that target this transcription factor for potential clinical applications.
Antibody Name:
PKNOX2 Antibody
Antibody SKU:
PACO01364
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human PREP-2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
PKNOX2; PREP2; Homeobox protein PKNOX2; Homeobox protein PREP-2; PBX/knotted homeobox 2
UniProt Protein Function:
PKNOX2: Belongs to the TALE/MEIS homeobox familyProtein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 11q24.2
UniProt Protein Details:
NCBI Summary:
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
