PKLR Rabbit Polyclonal Antibody (CAB12084)
- SKU:
- CAB12084
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | PKLR Rabbit Polyclonal Antibody |
SKU: | CAB12084 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 446-556 of human PKLR (NP_000289.1). |
Sequence: | PLSR DPTE VTAI GAVE AAFK CCAA AIIV LTTT GRSA QLLS RYRP RAAV IAVT RSAQ AARQ VHLC RGVF PLLY REPP EAIW ADDV DRRV QFGI ESGK LRGF LRVG DLVI VVT |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PK1; PKL; RPK; PKRL; PKLR |
Positive Sample: | Mouse heart,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, extracellular exosome |
Calculated MW: | 62kDa |
Observed MW: | 62kDa |
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5313 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |