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PKLR Monoclonal Antibody [PPKLRAT] (CPAB0111)

SKU:
CPAB0111
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PPKLRAT
Applications:
WB
ELISA
€149
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Description

system_update_alt Datasheet

PKLR Monoclonal Antibody [PPKLRAT] (CPAB0111)

The PKLR Polyclonal Antibody (CPAB0111) is specifically designed for research involving PKLR, a key enzyme involved in the glycolytic pathway. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding to the PKLR protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent tool for studies in metabolism and metabolic diseases.PKLR, or pyruvate kinase liver and red blood cell isoform, plays a crucial role in the final step of glycolysis, the process by which cells produce energy.

Dysregulation of PKLR has been implicated in a variety of diseases, including metabolic disorders and certain types of cancer. Research into PKLR function is essential for understanding the mechanisms underlying these conditions and developing potential therapeutic interventions.The PKLR Polyclonal Antibody is a valuable tool for scientists studying metabolism, cancer, and other diseases related to glycolytic pathways. Its high reactivity and specificity make it an ideal choice for detecting and analyzing PKLR protein levels in various experimental settings.

Product Name:PKLR Antibody
Product Sku:CPAB0111
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PKLR mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PKLR amino acids 47-574 purified from Ecoli.
Clone:PPKLRAT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:PKLR antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:PKLR is a pyruvate kinase which catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP. That is the rate-limiting step of glycolysis. PKLR gene encodes the L- and R-type isoenzymes through alternate splicing events controlled by different promoters. L-type isoform can also appear as a tetramer and is upregulated by glucose with implications in maturity-onset diabetes of the young.
Synonyms:PK1, PKL, RPK, pyruvate kinase isozyme R/L, Red cell/liver pyruvate kinase, PKRL.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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