The PKIB Polyclonal Antibody (PACO23281) is a valuable tool for researchers studying PKIB, a protein kinase inhibitor that plays key roles in cellular signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to PKIB, researchers can effectively detect and analyze the protein in a variety of cell types, making it an essential component for studies in signal transduction and cancer research.
PKIB is known for its ability to regulate protein kinase activity, impacting crucial cellular processes such as proliferation, differentiation, and apoptosis. Its involvement in signaling cascades makes it a promising target for investigations into diseases like cancer, where dysregulation of signaling pathways often plays a pivotal role. By gaining a deeper understanding of PKIB function, researchers can potentially uncover new therapeutic strategies for treating cancer and other related disorders.
Synthesized peptide derived from internal of human IPKB.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using IPKB antibody.
Immunofluorescence analysis of MCF-7 cells, using IPKB antibody.
Background:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains By similarity.
Synonyms:
PKI-beta; cAMP-dependent protein kinase inhibitor beta; PKIB; PRKACN2;
UniProt Protein Function:
PKIB: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Belongs to the PKI family.
UniProt Protein Details:
Protein type:Protein kinase, regulatory subunit; Inhibitor
Chromosomal Location of Human Ortholog: 6q22.31
Cellular Component: cytoplasm; nucleus
Molecular Function:cAMP-dependent protein kinase inhibitor activity
NCBI Summary:
This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
