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PKIB Antibody (PACO04712)

SKU:
PACO04712
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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PKIB Antibody (PACO04712)

The PKIB Polyclonal Antibody (PAC04712) is a valuable tool for researchers studying PKIB, a protein kinase inhibitor that plays a critical role in cell signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to PKIB, this antibody enables the detection and analysis of this important protein in various cell types, making it ideal for studies in signal transduction and cancer research.PKIB is known to regulate the activity of protein kinases, which are key players in cellular processes such as growth, proliferation, and differentiation.

Dysregulation of PKIB has been implicated in various diseases, including cancer and neurodegenerative disorders. By studying the function of PKIB, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for treatment.In summary, the PKIB Polyclonal Antibody is a powerful tool for investigating the role of PKIB in cellular signaling pathways and disease development. Its high specificity and reliability make it an essential component of any research project focused on understanding the complex biology of this important protein.

Antibody Name:PKIB Antibody
Antibody SKU:PACO04712
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human PKI Beta.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:PKIB; PRKACN2; cAMP-dependent protein kinase inhibitor beta; PKI-beta
UniProt Protein Function:PKIB: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Belongs to the PKI family.
UniProt Protein Details:

Protein type:Protein kinase, regulatory subunit; Inhibitor

Chromosomal Location of Human Ortholog: 6q22.31

Cellular Component: cytoplasm; nucleus

Molecular Function:cAMP-dependent protein kinase inhibitor activity

NCBI Summary:This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
UniProt Code:Q9C010
NCBI GenInfo Identifier:17378640
NCBI Gene ID:5570
NCBI Accession:Q9C010.1
UniProt Secondary Accession:Q9C010,Q567T9, Q5T0Z7, B2RCK2,
UniProt Related Accession:Q9C010
Molecular Weight:9,237 Da
NCBI Full Name:cAMP-dependent protein kinase inhibitor beta
NCBI Synonym Full Names:protein kinase (cAMP-dependent, catalytic) inhibitor beta
NCBI Official Symbol:PKIB  
NCBI Official Synonym Symbols:PRKACN2  
NCBI Protein Information:cAMP-dependent protein kinase inhibitor beta; PKI-beta; cAMP-dependent protein kinase inhibitor 2
UniProt Protein Name:cAMP-dependent protein kinase inhibitor beta
Protein Family:cAMP-dependent protein kinase
UniProt Gene Name:PKIB  
UniProt Entry Name:IPKB_HUMAN

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