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PKIA Antibody (PACO04711)

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SKU:
PACO04711
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323

Description

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PKIA Antibody (PACO04711)

The PKIA Polyclonal Antibody (PACO04711) is a high-quality antibody designed for researchers studying PKIA, a key protein kinase that plays a critical role in cellular signaling pathways. This antibody, produced in rabbits, has been validated for use in Western blot applications and is highly reactive with human samples.PKIA, also known as protein kinase A inhibitor alpha, is involved in the regulation of cell growth, differentiation, and survival. By binding to PKIA, this antibody allows for the detection and analysis of PKIA in various cell types, making it a valuable tool for studies in signal transduction, cancer biology, and drug development.

The importance of PKIA in cellular signaling and its potential as a therapeutic target in diseases like cancer and metabolic disorders make it an intriguing molecule for further research. By utilizing the PKIA Polyclonal Antibody, researchers can gain valuable insights into the role of PKIA in health and disease, ultimately leading to the development of novel therapeutic strategies.

Antibody Name:PKIA Antibody
Antibody SKU:PACO04711
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the N-terminal region of human Pki alpha.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:PKIA; PRKACN1; cAMP-dependent protein kinase inhibitor alpha; PKI-alpha; cAMP-dependent protein kinase inhibitor; muscle/brain isoform
UniProt Protein Function:PKIA: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Belongs to the PKI family.
UniProt Protein Details:

Protein type:Inhibitor

Chromosomal Location of Human Ortholog: 8q21.13

Cellular Component: cytoplasm; nucleus

Molecular Function:cAMP-dependent protein kinase inhibitor activity; protein binding

Biological Process: negative regulation of cAMP-dependent protein kinase activity; negative regulation of protein import into nucleus; negative regulation of transcription from RNA polymerase II promoter; regulation of G2/M transition of mitotic cell cycle

NCBI Summary:The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:P61925
NCBI GenInfo Identifier:5803127
NCBI Gene ID:5569
NCBI Accession:NP_006814.1
UniProt Secondary Accession:P61925,P04541, Q6IAV2,
UniProt Related Accession:P61925
Molecular Weight:
NCBI Full Name:cAMP-dependent protein kinase inhibitor alpha
NCBI Synonym Full Names:cAMP-dependent protein kinase inhibitor alpha
NCBI Official Symbol:PKIA  
NCBI Official Synonym Symbols:PRKACN1  
NCBI Protein Information:cAMP-dependent protein kinase inhibitor alpha
UniProt Protein Name:cAMP-dependent protein kinase inhibitor alpha
UniProt Synonym Protein Names:cAMP-dependent protein kinase inhibitor, muscle/brain isoform
Protein Family:Protein
UniProt Gene Name:PKIA  

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