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PKD2L1 Antibody (PACO43896)

SKU:
PACO43896
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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PKD2L1 Antibody (PACO43896)

The PKD2L1 Polyclonal Antibody (PAC043896) is a valuable tool for researchers studying PKD2L1, a protein involved in sensory signaling pathways. This antibody, generated in rabbits, exhibits high specificity for PKD2L1 in human samples and is validated for use in Western blot applications. By targeting the PKD2L1 protein, this antibody enables precise detection and analysis in various cell types, making it an excellent choice for studies in sensory biology and neurology research.PKD2L1, also known as polycystic kidney disease 2-like 1, plays a crucial role in sensory transduction processes, particularly in taste perception and mechanosensation.

Its involvement in sensory signaling pathways makes it a promising target for research in understanding sensory disorders and related conditions. Investigating the function of PKD2L1 is essential for developing potential treatments for sensory-related diseases and disorders.Overall, the PKD2L1 Polyclonal Antibody is a reliable tool for researchers aiming to explore the role of PKD2L1 in sensory biology and related fields, offering valuable insights into sensory signaling mechanisms and potential therapeutic avenues.

Antibody Name:PKD2L1 Antibody (PACO43896)
Antibody SKU:PACO43896
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Polycystic kidney disease 2-like 1 protein (561-805AA)
Form:Liquid
Storage Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human small intestine tissue using PACO43896 at dilution of 1:100.
Background:Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
Synonyms:Polycystic kidney disease 2-like 1 protein (Polycystin-2 homolog) (Polycystin-2L1) (Polycystin-L) (Polycystin-L1), PKD2L1, PKD2L PKDL TRPP3
UniProt Protein Function:PKD2L1: May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling. Belongs to the polycystin family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Channel, cationChromosomal Location of Human Ortholog: 10q24Cellular Component: cell surface; endoplasmic reticulum; intracellular membrane-bound organelle; membrane; nonmotile primary cilium; plasma membrane; receptor complexMolecular Function: alpha-actinin binding; calcium activated cation channel activity; calcium channel activity; calcium ion binding; calcium-activated potassium channel activity; cation channel activity; cation transmembrane transporter activity; cytoskeletal protein binding; identical protein binding; muscle alpha-actinin binding; protein binding; sodium channel activity; sour taste receptor activityBiological Process: cation transport; detection of chemical stimulus involved in sensory perception of sour taste; detection of mechanical stimulus; sensory perception of sour taste; smoothened signaling pathway
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:Q9P0L9
NCBI GenInfo Identifier:23821938
NCBI Gene ID:9033
NCBI Accession:Q9P0L9.1
UniProt Secondary Accession:Q9P0L9,O75972, Q5W039, Q9UP35, Q9UPA2
UniProt Related Accession:Q9P0L9
Molecular Weight:88,472 Da
NCBI Full Name:Polycystic kidney disease 2-like 1 protein
NCBI Synonym Full Names:polycystin 2 like 1, transient receptor potential cation channel
NCBI Official Symbol:PKD2L1  
NCBI Official Synonym Symbols:PCL; PKDL; PKD2L; TRPP3  
NCBI Protein Information:polycystic kidney disease 2-like 1 protein
UniProt Protein Name:Polycystic kidney disease 2-like 1 protein
UniProt Synonym Protein Names:Polycystin-2 homolog; Polycystin-2L1; Polycystin-L; Polycystin-L1
Protein Family:Polycystic kidney disease 2-like 1 protein
UniProt Gene Name:PKD2L1  
UniProt Entry Name:PK2L1_HUMAN
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