| UniProt Protein Function: | PKD2L1: May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling. Belongs to the polycystin family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Channel, cationChromosomal Location of Human Ortholog: 10q24Cellular Component: cell surface; endoplasmic reticulum; intracellular membrane-bound organelle; membrane; nonmotile primary cilium; plasma membrane; receptor complexMolecular Function: alpha-actinin binding; calcium activated cation channel activity; calcium channel activity; calcium ion binding; calcium-activated potassium channel activity; cation channel activity; cation transmembrane transporter activity; cytoskeletal protein binding; identical protein binding; muscle alpha-actinin binding; protein binding; sodium channel activity; sour taste receptor activityBiological Process: cation transport; detection of chemical stimulus involved in sensory perception of sour taste; detection of mechanical stimulus; sensory perception of sour taste; smoothened signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9P0L9 |
| NCBI GenInfo Identifier: | 23821938 |
| NCBI Gene ID: | 9033 |
| NCBI Accession: | Q9P0L9.1 |
| UniProt Secondary Accession: | Q9P0L9,O75972, Q5W039, Q9UP35, Q9UPA2 |
| UniProt Related Accession: | Q9P0L9 |
| Molecular Weight: | 88,472 Da |
| NCBI Full Name: | Polycystic kidney disease 2-like 1 protein |
| NCBI Synonym Full Names: | polycystin 2 like 1, transient receptor potential cation channel |
| NCBI Official Symbol: | PKD2L1Â Â |
| NCBI Official Synonym Symbols: | PCL; PKDL; PKD2L; TRPP3Â Â |
| NCBI Protein Information: | polycystic kidney disease 2-like 1 protein |
| UniProt Protein Name: | Polycystic kidney disease 2-like 1 protein |
| UniProt Synonym Protein Names: | Polycystin-2 homolog; Polycystin-2L1; Polycystin-L; Polycystin-L1 |
| Protein Family: | Polycystic kidney disease 2-like 1 protein |
| UniProt Gene Name: | PKD2L1Â Â |
| UniProt Entry Name: | PK2L1_HUMAN |
