PKD2L1 Antibody (PACO18348)
- SKU:
- PACO18348
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
PKD2L1 Antibody (PACO18348)
The PKD2L1 Antibody (PAC018348) is a powerful tool for researchers studying the PKD2L1 protein, a member of the polycystin family involved in various cellular functions. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the PKD2L1 protein, this antibody enables accurate detection and analysis in different cell types, making it perfect for investigations in molecular biology and cell signaling research.
PKD2L1, also known as polycystic kidney disease 2-like 1, plays a crucial role in cellular processes such as calcium signaling and ion channel regulation. Its involvement in these pathways makes it a key player in diseases like polycystic kidney disease and other genetic disorders. Research into the function and regulation of PKD2L1 is essential for developing targeted therapies for these conditions, as well as gaining insights into its broader impact on cell physiology.
| Antibody Name: | PKD2L1 Antibody (PACO18348) |
| Antibody SKU: | PACO18348 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human PKD2L1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18348(PKD2L1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. |
| Synonyms: | polycystic kidney disease 2-like 1 |
| UniProt Protein Function: | PKD2L1: May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling. Belongs to the polycystin family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Channel, cationChromosomal Location of Human Ortholog: 10q24Cellular Component: cell surface; endoplasmic reticulum; intracellular membrane-bound organelle; membrane; nonmotile primary cilium; plasma membrane; receptor complexMolecular Function: alpha-actinin binding; calcium activated cation channel activity; calcium channel activity; calcium ion binding; calcium-activated potassium channel activity; cation channel activity; cation transmembrane transporter activity; cytoskeletal protein binding; identical protein binding; muscle alpha-actinin binding; protein binding; sodium channel activity; sour taste receptor activityBiological Process: cation transport; detection of chemical stimulus involved in sensory perception of sour taste; detection of mechanical stimulus; sensory perception of sour taste; smoothened signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9P0L9 |
| NCBI GenInfo Identifier: | 23821938 |
| NCBI Gene ID: | 9033 |
| NCBI Accession: | Q9P0L9.1 |
| UniProt Secondary Accession: | Q9P0L9,O75972, Q5W039, Q9UP35, Q9UPA2 |
| UniProt Related Accession: | Q9P0L9 |
| Molecular Weight: | 88,472 Da |
| NCBI Full Name: | Polycystic kidney disease 2-like 1 protein |
| NCBI Synonym Full Names: | polycystin 2 like 1, transient receptor potential cation channel |
| NCBI Official Symbol: | PKD2L1Â Â |
| NCBI Official Synonym Symbols: | PCL; PKDL; PKD2L; TRPP3Â Â |
| NCBI Protein Information: | polycystic kidney disease 2-like 1 protein |
| UniProt Protein Name: | Polycystic kidney disease 2-like 1 protein |
| UniProt Synonym Protein Names: | Polycystin-2 homolog; Polycystin-2L1; Polycystin-L; Polycystin-L1 |
| Protein Family: | Polycystic kidney disease 2-like 1 protein |
| UniProt Gene Name: | PKD2L1Â Â |
| UniProt Entry Name: | PK2L1_HUMAN |
| Antibodies |
| PKD2L1 Antibody (PACO11268) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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