The Polycystin-2 Polyclonal Antibody (CAB3625) is a vital tool for researchers studying the polycystin-2 protein, which plays a crucial role in polycystic kidney disease (PKD), a genetic disorder characterized by the growth of fluid-filled cysts in the kidneys. This antibody, generated in rabbits, exhibits high specificity for human samples and is validated for use in various applications, including Western blotting.Polycystin-2 is a calcium-permeable cation channel that is primarily expressed in the kidneys and is involved in the regulation of calcium signaling and fluid flow in renal tubules.
Mutations in the gene encoding polycystin-2 have been linked to the development of PKD, making it a key target for research in the field of kidney disease.By utilizing the Polycystin-2 Polyclonal Antibody, researchers can investigate the expression levels and localization of polycystin-2 in different cell types and tissues, providing valuable insights into its function and potential as a therapeutic target for PKD. This antibody is an essential tool for furthering our understanding of the molecular mechanisms underlying PKD and developing novel therapies for this devastating disease.
Product Name:
PKD2 Rabbit Polyclonal Antibody
SKU:
CAB3625
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 879-968 of human PKD2 (NP_000288.1).
This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2.
Purification Method:
Affinity purification
Gene ID:
5311
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PKD2 antibody (CAB3625) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
