The PKD1L3 Polyclonal Antibody (PAC047974) is a valuable tool for researchers studying PKD1L3, a protein involved in taste perception and sensory signaling. This antibody, produced in rabbits, has high specificity for PKD1L3 and is suitable for use in various applications such as Western blot and immunohistochemistry.PKD1L3 is a member of the polycystin family and is primarily expressed in taste receptor cells where it plays a key role in sour taste perception. By targeting PKD1L3 with this antibody, researchers can investigate its function in taste transduction pathways and gain insights into how taste perception is regulated at the molecular level.
Overall, the PKD1L3 Polyclonal Antibody is a reliable tool for researchers interested in understanding the molecular mechanisms underlying taste perception and sensory biology. Its specificity and versatility make it a valuable asset for studies related to taste sensation, gustatory physiology, and sensory processing.
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO47974 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO47974 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human heart tissue using PACO47974 at dilution of 1:100.
Background:
Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
PKD1L3: May function as an ion-channel regulator. May function with PKD2L1 as heteromeric taste channels. Belongs to the polycystin family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 16q22.2Cellular Component: cell surface; plasma membrane; receptor complexMolecular Function: calcium channel activity; cation channel activity; cation transmembrane transporter activity; protein binding; sour taste receptor activityBiological Process: cation transport; detection of chemical stimulus involved in sensory perception of sour taste; detection of mechanical stimulus; sensory perception of sour taste
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores.[provided by RefSeq, Apr 2009]
