The PKD1L1 Polyclonal Antibody (PAC053138) is a valuable tool for researchers studying the PKD1L1 protein, a member of the polycystin family involved in renal and cardiovascular development. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PKD1L1 protein, this antibody enables accurate detection and analysis in various cell types, making it well-suited for research in nephrology and cardiovascular biology.
PKD1L1 is known for its role in kidney and heart development, making it a key target for studying related diseases such as polycystic kidney disease and various cardiovascular disorders. Understanding the function of PKD1L1 is essential for advancing research and developing targeted therapies for these conditions. The PKD1L1 Polyclonal Antibody provides researchers with a reliable tool to investigate the function and expression of PKD1L1 in various biological contexts.
Immunohistochemistry of paraffin-embedded human liver tissue using PACO53138 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO53138 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.
Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the polycystin protein family containing 11 transmembrane domains, a receptor for egg jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. The encoded protein may play a role in the male reproductive system. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
