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PKC zeta Monoclonal Antibody

SKU:
CAB23777
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

PKC zeta Monoclonal Antibody (CAB23777)

The PKC-Zeta Monoclonal Antibody is a highly specific tool for researchers studying Protein Kinase C Zeta (PKC-Zeta), a key player in various signaling pathways related to cell proliferation, differentiation, and survival. This antibody, produced through hybridoma technology, exhibits strong reactivity with human, mouse, and rat samples, making it versatile for use in immunofluorescence, immunoprecipitation, and flow cytometry.PKC-Zeta is a member of the PKC family of serine/threonine kinases and is involved in the regulation of various cellular processes, including cell cycle progression, apoptosis, and immune responses.

Dysregulation of PKC-Zeta has been linked to the development of cancer, diabetes, and neurological disorders, making it a promising target for therapeutic intervention.In conclusion, the PKC-Zeta Monoclonal Antibody is a valuable tool for researchers delving into the molecular mechanisms underlying cell signaling and disease pathogenesis. Its high specificity and reactivity allow for precise detection and analysis of PKC-Zeta in various experimental settings, paving the way for new insights into therapeutic strategies targeting this critical kinase.

Product Name:PKC zeta Monoclonal Antibody
Product Code:CAB23777
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC61755
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:293T, Hep G2
Cellular Location:Cell junction, Cytoplasm, Endosome

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.

Immunogen:Recombinant protein of human PKC zeta.
Sequence:Email for sequence
Synonyms:PRKCZ, PKC-ZETA, PKC2, protein kinase C zeta
Calculated MW:46kDa/56kDa/67kDa
Observed MW:75kDa

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