The PKC-gamma Rabbit Monoclonal Antibody (CAB9565) is a valuable tool for researchers studying protein kinase C gamma (PKC-gamma), a key regulator of various cellular processes including cell growth, differentiation, and survival. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting PKC-gamma protein in human samples, making it an essential reagent for Western blotting and immunohistochemistry applications.PKC-gamma is known for its involvement in numerous signaling pathways related to cancer, neurodegenerative diseases, and immune responses.
By targeting PKC-gamma, researchers can gain valuable insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic strategies. The PKC-gamma Rabbit Monoclonal Antibody enables precise detection and analysis of PKC-gamma expression in diverse cell types, providing a versatile tool for cutting-edge research in the fields of cancer biology, neuroscience, and immunology.
Product Name:
PKC gamma Rabbit Monoclonal Antibody
SKU:
CAB9565
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 604-697 of human PKC gamma (P05129).
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5582
Clone Number:
ARC1637
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PKC gamma Rabbit mAb (CAB9565) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
