The PKC epsilon Rabbit Monoclonal Antibody (CAB4998) is a cutting-edge research tool designed for studying Protein Kinase C epsilon (PKCε), an important enzyme involved in cell signaling and regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards PKCε in various cell types and tissues.PKCε is a member of the PKC family of kinases and plays a crucial role in various cellular processes, including cell growth, survival, and differentiation. Dysregulation of PKCε has been implicated in several diseases, such as cancer, cardiovascular disorders, and neurological conditions.
Therefore, understanding the function and regulation of PKCε is essential for developing targeted therapies and interventions.The PKC epsilon Rabbit Monoclonal Antibody (CAB4998) is validated for use in Western blotting, immunofluorescence, and immunohistochemistry applications, allowing for precise detection and analysis of PKCε expression and localization. Researchers in the fields of molecular biology, biochemistry, and pharmacology can rely on this antibody to further investigate the role of PKCε in disease pathogenesis and therapeutic development.
Product Name:
PKC epsilon Rabbit Monoclonal Antibody
SKU:
CAB4998
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human PKC epsilon (Q02156).
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.
Purification Method:
Affinity purification
Gene ID:
5581
Clone Number:
ARC1270
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse lung, using PKC epsilon Rabbit mAb (CAB4998) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
