The PKC-alpha Monoclonal Antibody (CAB23231) is a valuable tool for researchers studying protein kinase C alpha (PKC-alpha), a key regulator of cell signaling pathways. This monoclonal antibody, developed using advanced technology, specifically targets PKC-alpha and is highly reactive with human samples.PKC-alpha is a critical player in cellular processes such as cell growth, differentiation, and apoptosis. Dysregulation of PKC-alpha has been linked to various diseases, including cancer, neurological disorders, and cardiovascular diseases. By using this monoclonal antibody in experiments such as Western blotting, researchers can effectively detect and analyze PKC-alpha levels in different cell types.
Understanding the role of PKC-alpha in signaling cascades and its involvement in disease pathology can provide insights into potential therapeutic targets. The PKC-alpha Monoclonal Antibody is a valuable tool for researchers in the fields of molecular biology, biochemistry, and pharmacology who are dedicated to unraveling the complexities of PKC-alpha signaling and its implications in human health and disease.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
Purification Method:
Affinity purification
Gene ID:
5578
Clone Number:
ARC58845
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Immunofluorescence analysis of HeLa cells using PKC alpha Rabbit mAb (CAB23231) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
