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PKC alpha Monoclonal Antibody (CAB23187)

SKU:
CAB23187
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

PKC alpha Monoclonal Antibody (CAB23187)

The PKC-alpha Monoclonal Antibody (CAB23187) is a valuable tool for researchers studying protein kinase C alpha (PKC-alpha), an enzyme involved in cellular signaling pathways regulating cell growth, differentiation, and apoptosis. This monoclonal antibody, produced in mouse, specifically targets PKC-alpha and is highly reactive with human samples, making it suitable for a wide range of applications in research.PKC-alpha is a key player in various cellular processes, including gene expression, cell migration, and immune response modulation. Dysregulation of PKC-alpha has been implicated in numerous diseases, such as cancer, neurological disorders, and cardiovascular conditions.

By targeting PKC-alpha with this antibody, researchers can better understand its role in disease development and progression, paving the way for potential therapeutic interventions.Overall, the PKC-alpha Monoclonal Antibody (CAB23187) offers a reliable and specific tool for investigating the functions of PKC-alpha in various biological contexts, making it an essential reagent for studies in cell biology, pharmacology, and disease research.

Product Name:PKC alpha Monoclonal Antibody
Product Code:CAB23187
Reactivity:Human, Mouse
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC58853
Reactivity:Human, Mouse
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:1000-1:5000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:HeLa, Jurkat, NIH/3T3, Mouse brain
Cellular Location:Cell membrane, Cytoplasm, Mitochondrion membrane, Nucleus, Peripheral membrane protein

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

Immunogen:A synthesized peptide derived from human PKC alpha.
Sequence:Email for sequence
Synonyms:AAG6, PKCA, PRKACA, PKCI+/-, PKCalpha, PKC-alpha
Calculated MW:77kDa
Observed MW:80kDa

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