The PIWI-like Protein 1 Polyclonal Antibody (CAB2150) is a valuable tool for researchers studying PIWI-like Protein 1, a key player in RNA metabolism and gene silencing processes. This antibody, developed through rabbit immunization, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding specifically to PIWI-like Protein 1, it enables precise detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology and RNA regulation studies.PIWI-like Protein 1, also known as PIWIL1, is essential for the biogenesis and function of PIWI-interacting RNAs (piRNAs), which play crucial roles in transposon silencing, germ cell development, and epigenetic regulation.
Dysregulation of PIWI-like Protein 1 expression has been linked to various diseases, including cancer and infertility, making it a promising target for therapeutic interventions. Research on PIWI-like Protein 1 function is vital for understanding its role in disease pathogenesis and developing targeted treatments to modulate its activity.
Product Name:
PIWIL1 Rabbit Polyclonal Antibody
SKU:
CAB2150
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of mouse PIWIL1 (NP_067286.1).
Enables several functions, including RNA binding activity; mRNA cap binding complex binding activity; and polysome binding activity. Involved in negative regulation of transposition; piRNA metabolic process; and spermatogenesis, exchange of chromosomal proteins. Located in chromatoid body; dense body; and nucleus. Is expressed in genitourinary system. Orthologous to human PIWIL1 (piwi like RNA-mediated gene silencing 1).
Purification Method:
Affinity purification
Gene ID:
57749
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PIWIL1 Rabbit pAb (CAB2150) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
