The Pituitary Homeobox 2 (PITX2) Monoclonal Antibody is a powerful tool for researchers studying the PITX2 protein, a transcription factor involved in development and disease. This antibody, produced in a monoclonal format, offers high specificity and sensitivity for detecting PITX2 in various experimental applications, including immunofluorescence and flow cytometry. Its reactivity with human samples has been extensively validated, ensuring reliable and reproducible results in research settings.PITX2 is known for its essential roles in embryonic development, particularly in the formation of the pituitary gland and other tissues. In addition, abnormalities in PITX2 expression have been implicated in various medical conditions, including pituitary disorders and certain cancers.
By targeting PITX2 with this monoclonal antibody, researchers can gain valuable insights into its function and its potential as a diagnostic or therapeutic target in disease settings.Overall, the PITX2 Monoclonal Antibody offers a valuable tool for investigating the role of PITX2 in development and disease. Its high specificity and sensitivity, along with its validated reactivity with human samples, make it an essential reagent for studies in molecular biology, developmental biology, and cancer research.
Product Name:
Pituitary homeobox 2 (PITX2) Monoclonal Antibody
SKU:
CAB22173
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Pituitary homeobox 2 (PITX2) (NP_700475.1).
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
5308
Clone Number:
ARC56103
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of HeLa, using Pituitary homeobox 2 (PITX2) antibody (CAB22173) at1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
