The PITRM1 Polyclonal Antibody (CAB8362) is a valuable tool for researchers studying PITRM1, a mitochondrial peptidasome enzyme involved in the degradation of mitochondrial targeting peptides. This antibody, generated in rabbits, is highly specific and reactive with human samples, making it an ideal choice for various research applications.PITRM1 plays a crucial role in maintaining mitochondrial homeostasis by degrading short peptides that target proteins to the mitochondria. Dysregulation of PITRM1 has been linked to neurodegenerative diseases and metabolic disorders, highlighting its importance in cellular function.
By using the PITRM1 Polyclonal Antibody, researchers can study the expression and localization of PITRM1 in different cell types and tissues, providing valuable insights into its biological functions.Whether investigating mitochondrial dysfunction in neurodegenerative disorders or exploring the role of PITRM1 in metabolic pathways, the CAB8362 antibody is a reliable tool for researchers seeking to deepen their understanding of PITRM1 biology. Its high specificity and sensitivity in applications such as Western blotting make it a valuable asset for studies in mitochondrial biology and related fields.
Product Name:
PITRM1 Rabbit Polyclonal Antibody
SKU:
CAB8362
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 758-1037 of human PITRM1 (NP_055704.2).
The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease.
Purification Method:
Affinity purification
Gene ID:
10531
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PITRM1 Rabbit pAb (CAB8362) at 1:6600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
