The PITPNC1 Antibody (PAC042502) is a valuable tool for researchers studying PITPNC1, a protein involved in lipid metabolism and cancer progression. This polyclonal antibody, produced in rabbits, demonstrates high reactivity with human samples and is suitable for use in Western blot experiments. By targeting the PITPNC1 protein, researchers can analyze its expression and function in various cell types, making it an essential tool for investigations in cancer biology and lipid signaling pathways.PITPNC1, also known as phosphatidylinositol transfer protein cytoplasmic 1, plays a crucial role in lipid transport and signaling, making it a key player in processes like cell growth, proliferation, and survival.
Dysregulation of PITPNC1 has been linked to cancer development and progression, making it a promising target for therapeutic interventions in cancer treatment. By studying the function of PITPNC1, researchers can gain insights into its role in cancer biology and potentially discover new therapeutic strategies for combating cancer.
Antibody Name:
PITPNC1 Antibody (PACO42502)
Antibody SKU:
PACO42502
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Cytoplasmic phosphatidylinositol transfer protein 1 protein (1-268AA)
Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO42502 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO42502 at dilution of 1:100.
Background:
Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. Able to transfer phosphatidylinositol in vitro.
Synonyms:
Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta), PITPNC1
UniProt Protein Function:
PITPNC1: Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. Able to transfer phosphatidylinositol in vitro. Belongs to the PtdIns transfer protein family. PI transfer class IIB subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid-bindingChromosomal Location of Human Ortholog: 17q24.2Cellular Component: cytoplasm; nucleoplasmMolecular Function: lipid binding; phosphatidylinositol transporter activity; protein bindingBiological Process: phospholipid transport; signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the phosphatidylinositol transfer protein family. The encoded cytoplasmic protein plays a role in multiple processes including cell signaling and lipid metabolism by facilitating the transfer of phosphatidylinositol between membrane compartments. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 1. [provided by RefSeq, May 2012]
