The PITPNB Polyclonal Antibody (PAC022500) is a valuable tool for researchers studying PITPNB, a protein involved in intracellular lipid transport and signaling pathways. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to PITPNB, researchers can accurately detect and analyze the protein in various cell types, making it an essential tool for studies in lipid metabolism and cell signaling pathways.PITPNB is known for its role in phosphatidylinositol and phosphatidylcholine metabolism, which are critical for cell growth, survival, and membrane integrity.
By understanding the function of PITPNB, researchers can gain insights into lipid-related disorders, cancer progression, and neurodegenerative diseases. The PITPNB Polyclonal Antibody is a valuable asset for unraveling the complex mechanisms of lipid metabolism and signaling pathways, ultimately leading to the development of targeted therapies for various diseases.
Antibody Name:
PITPNB Antibody (PACO22500)
Antibody SKU:
PACO22500
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human PITPNB.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HepG2 cells, using PITPNB antibody.
Background:
Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
Synonyms:
Phosphatidylinositol transfer protein beta isoform; PI-TP-beta; PI-TPbeta; PIPNB; PPI2
UniProt Protein Function:
PITPNB: transfers phosphatidylinositol, phosphatidylcholine and sphingomyelin between membrane bilayers. Associates mainly with the trans-Golgi network. Ser-261 is constitutively phosphorylated.Protein type: Lipid-bindingChromosomal Location of Human Ortholog: 22q12.1Cellular Component: endoplasmic reticulum membrane; Golgi membraneBiological Process: phospholipid transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]
