The Pip4k2a Polyclonal Antibody (CAB7446) is specifically designed for research involving Pip4k2a, a key enzyme involved in phosphatidylinositol signaling pathways. The antibody, produced using rabbit immunization, is highly reactive with human and mouse samples, and has been validated for use in Western blot and immunohistochemistry applications. It binds to the Pip4k2a protein, allowing for precise detection and analysis in various cell types, making it an essential tool for studies in cell signaling, metabolism, and cancer research.Pip4k2a, also known as phosphatidylinositol 5-phosphate 4-kinase type 2 alpha, is crucial for regulating cellular processes such as cell growth, proliferation, and survival.
Its involvement in phosphatidylinositol signaling pathways implicates it in diseases such as cancer, diabetes, and neurodegenerative disorders. Research into Pip4k2a is essential for understanding its role in these diseases and for developing targeted therapies that can modulate its activity.Overall, the Pip4k2a Polyclonal Antibody (CAB7446) provides researchers with a valuable tool for studying the function and regulation of the Pip4k2a enzyme, shedding light on its potential as a therapeutic target in various disease contexts.
Product Name:
PIP4K2A Rabbit Polyclonal Antibody
SKU:
CAB7446
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-350 of human PIP4K2A (NP_005019.2).
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family.
Purification Method:
Affinity purification
Gene ID:
5305
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PIP4K2A Rabbit pAb (CAB7446) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
