The Pink1 Polyclonal Antibody (CAB24745) is a vital tool for researchers studying the Pink1 protein, which is involved in mitochondrial quality control and maintenance. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to Pink1, this antibody enables accurate detection and analysis of the protein in various cell types, making it an essential tool for studies in neurodegenerative diseases and mitochondrial dysfunction.Pink1, or PTEN-induced putative kinase 1, plays a crucial role in mitochondrial health by regulating processes such as mitophagy and mitochondrial biogenesis.
Dysregulation of Pink1 has been implicated in the pathogenesis of Parkinson's disease and other neurodegenerative disorders. Understanding the function of Pink1 is essential for developing targeted therapies to treat these debilitating conditions and improve mitochondrial function in affected individuals. By utilizing the Pink1 Polyclonal Antibody (CAB24745), researchers can gain valuable insights into the role of Pink1 in mitochondrial biology and disease pathology, ultimately driving advancements in the field of neuroscience and personalized medicine.
Product Name:
PINK1 Polyclonal Antibody
SKU:
CAB24745
Size:
100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PINK1 (NP_115785.1).
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.
Purification Method:
Affinity purification
Gene ID:
65018
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat heart using PINK1 Rabbit pAb(CAB24745) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
