PIN1 Rabbit Polyclonal Antibody (CAB2106)
- SKU:
- CAB2106
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
Product Name: | PIN1 Rabbit Polyclonal Antibody |
SKU: | CAB2106 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human Pin1 (NP_006212.1). |
Sequence: | MADE EKLP PGWE KRMS RSSG RVYY FNHI TNAS QWER PSGN SSSG GKNG QGEP ARVR CSHL LVKH SQSR RPSS WRQE KITR TKEE ALEL INGY IQKI KSGE EDFE SLAS QFSD CSSA KARG DLGA FSRG QMQK PFED ASFA LRTG EMSG PVFT DSGI HIIL RTE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 |
Synonyms: | DOD; UBL5; Pin1 |
Positive Sample: | 293F,Mouse brain,PC-12,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, Nucleus speckle. |
Calculated MW: | 18kDa |
Observed MW: | 18kDa |
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5300 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |