The Pin1 Polyclonal Antibody (CAB2106) is a valuable tool for researchers studying Pin1, a key player in regulating cellular processes such as cell cycle progression, DNA damage response, and cell differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.Pin1 is a unique enzyme that is involved in the post-translational modifications of proteins by catalyzing the isomerization of specific phosphorylated serine or threonine residues. Its role in regulating protein conformation and function makes it a target of interest in various biological processes, including cancer development, neurodegenerative diseases, and aging.
By using the Pin1 Polyclonal Antibody, researchers can detect and analyze the expression levels of Pin1 in different cell types, providing insights into its functions and potential therapeutic applications. This antibody is particularly suitable for studies in cell biology, molecular biology, and cancer research, where understanding the role of Pin1 can lead to the development of novel treatment strategies.
Product Name:
PIN1 Rabbit Polyclonal Antibody
SKU:
CAB2106
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human Pin1 (NP_006212.1).
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5300
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Pin1 Rabbit pAb (CAB2106) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
