The Pin1 Polyclonal Antibody (CAB13665) is a valuable tool for researchers studying Pin1, a key enzyme involved in cell cycle regulation and signaling pathways. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blotting applications. By binding specifically to the Pin1 protein, this antibody enables accurate detection and analysis of Pin1 expression in various cell types.Pin1 is a critical regulator of cell proliferation, differentiation, and survival, making it a target of interest in cancer research and other diseases involving abnormal cell growth. Dysregulation of Pin1 has been linked to the development and progression of various cancers, making it a potential therapeutic target for anti-cancer treatments.
By studying Pin1 activity and expression levels, researchers can gain valuable insights into the mechanisms of tumorigenesis and identify new strategies for cancer therapy.In conclusion, the Pin1 Polyclonal Antibody (CAB13665) is a reliable tool for investigating the role of Pin1 in cellular processes and disease development. Its high specificity and sensitivity make it ideal for research in cancer biology, cell signaling, and drug discovery. By using this antibody, researchers can advance our understanding of Pin1 function and potentially uncover new therapeutic opportunities for cancer treatment.
Product Name:
PIN1 Rabbit Polyclonal Antibody
SKU:
CAB13665
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human Pin1 (NP_006212.1).
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5300
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Pin1 Rabbit pAb (CAB13665) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
