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PIN1 Monoclonal Antibody [P3G8AT] (CPAB0129)

SKU:
CPAB0129
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
P3G8AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

PIN1 Monoclonal Antibody [P3G8AT] (CPAB0129)

The PIN1 Polyclonal Antibody (CPAB0129) is an essential tool for researchers studying the function of PIN1, a key enzyme involved in cell cycle regulation and signaling pathways. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it perfect for use in Western blot applications to detect PIN1 protein expression.PIN1 is a peptidyl-prolyl cis/trans isomerase that plays a pivotal role in phosphorylation-dependent signaling cascades, such as those involved in cancer development and progression. Its dysregulation has been implicated in various diseases, making it an attractive target for therapeutic interventions.

By using the PIN1 Polyclonal Antibody, researchers can gain valuable insights into the molecular mechanisms underlying PIN1 function and its potential implications in disease pathogenesis.This antibody is a valuable tool for laboratories conducting research in cell biology, oncology, and signal transduction pathways. Its ability to specifically recognize PIN1 protein enables accurate detection and analysis in various cell types, facilitating a better understanding of its role in physiological and pathological processes. Unlock the potential of your research with the precise and reliable detection capabilities of the PIN1 Polyclonal Antibody.

Product Name:PIN1 Antibody
Product Sku:CPAB0129
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PIN1 mAb is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PIN1 amino acids 1-163 purified from Ecoli.
Clone:P3G8AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:
Isotype:IgG1
Background:Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA, PLK I, Wee, and Myt1 kinases), several transcription factors like β-Catenin, c-Jun, and the tumor suppressor protein p53, and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1.
Synonyms:Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, EC 5.2.1.8, Rotamase Pin1, PPIase Pin1, DOD, UBL5, PIN1, PPIase.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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