PIM1 Rabbit Polyclonal Antibody (CAB14210)
- SKU:
- CAB14210
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | PIM1 Rabbit Polyclonal Antibody |
SKU: | CAB14210 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-313 of human PIM1 (NP_001230115.1). |
Sequence: | MPHE PHEP LTPP FSAL PDPA GAPS RRQS RQRP QLSS DSPS AFRA SRSH SRNA TRSH SHSH SPRH SLRH SPGS GSCG SSSG HRPC ADIL EVGM LLSK INSL AHLR AAPC NDLH ATKL APGK EKEP LESQ YQVG PLLG SGGF GSVY SGIR VSDN LPVA IKHV EKDR ISDW GELP NGTR VPME VVLL KKVS SGFS GVIR LLDW FERP DSFV LILE RPEP VQDL FDFI TERG ALQE ELAR SFFW QVLE AVRH CHNC GVLH RDIK DENI LIDL NRGE LKLI DFGS GALL KDTV YTDF DGTR VYSP PEWI RYHR YHGR S |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 |
Synonyms: | PIM; PIM1 |
Positive Sample: | H460,Mouse kidney,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Nucleus. |
Calculated MW: | 36kDa |
Observed MW: | 35kDa |
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).
Purification Method: | Affinity purification |
Gene ID: | 5292 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |