null

PILRB Antibody (PACO42334)

SKU:
PACO42334
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • PILRB Antibody PACO42334
  • PILRB Antibody PACO42334
  • PILRB Antibody PACO42334
€339

Description

system_update_altDatasheetsystem_update_altMSDS

PILRB Antibody (PACO42334)

The PILRB Polyclonal Antibody (PAC04234) is a valuable tool for researchers studying PILRB, a cell surface receptor involved in immune regulation and modulation. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it an ideal choice for immunological and cancer research studies. Validated for use in Western blot applications, this antibody binds to the PILRB protein, allowing for accurate detection and analysis across different cell types.PILRB, also known as paired immunoglobin-like receptor B, plays a key role in immune response modulation by regulating inflammation and inhibiting immune reactions.

Its involvement in immune homeostasis highlights its potential as a therapeutic target for diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Research into the function of PILRB is essential for the development of new treatment strategies that target immune function in these disease contexts.

Antibody Name:PILRB Antibody (PACO42334)
Antibody SKU:PACO42334
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Paired immunoglobulin-like type 2 receptor β protein (20-191AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human kidney tissue using PACO42334 at dilution of 1:100.
Product ImageImmunofluorescent analysis of Hela cells using PACO42334 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageImmunohistochemistry of paraffin-embedded human gastric cancer using PACO42334 at dilution of 1:100.
Background:Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.
Synonyms:Paired immunoglobulin-like type 2 receptor β (Activating receptor PILR-beta) (Cell surface receptor FDFACT), PILRB, FDFACT
UniProt Protein Function:PILRB: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: integral to plasma membrane

Molecular Function:protein binding

Biological Process: transmembrane receptor protein tyrosine kinase activation (dimerization); transmembrane receptor protein tyrosine kinase signaling pathway

NCBI Summary:The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]
UniProt Code:Q9UKJ0
NCBI GenInfo Identifier:74761987
NCBI Gene ID:29990
NCBI Accession:Q9UKJ0.1
UniProt Secondary Accession:Q9UKJ0,Q69YF9, Q9HBS0,
UniProt Related Accession:Q9UKJ0
Molecular Weight:29,630 Da
NCBI Full Name:Paired immunoglobulin-like type 2 receptor beta
NCBI Synonym Full Names:paired immunoglobin-like type 2 receptor beta
NCBI Official Symbol:PILRB  
NCBI Official Synonym Symbols:FDFACT1; FDFACT2  
NCBI Protein Information:paired immunoglobulin-like type 2 receptor beta; activating receptor PILR-beta; activating receptor PILRbeta; cell surface receptor FDFACT; cell surface receptor FDFACT1; cell surface receptor FDFACT2; paired immunoglobin-like receptor beta; paired immunoglobulin-like receptor beta
UniProt Protein Name:Paired immunoglobulin-like type 2 receptor beta
UniProt Synonym Protein Names:Activating receptor PILR-beta; Cell surface receptor FDFACT
Protein Family:Paired immunoglobulin-like type 2 receptor
UniProt Gene Name:PILRB  
UniProt Entry Name:PILRB_HUMAN
ELISA Kits
Human PILRB / Paired immunoglobulin-like type 2 receptor beta ELISA Kit
Human Paired immunoglobulin-like type 2 receptor beta (PILRB) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

Related Products