The PILRB Polyclonal Antibody (PAC016869) is a valuable tool for researchers studying the PILRB protein, a member of the paired immunoglobulin-like receptor B (PILRB) family. This antibody, raised in rabbits, is highly specific for human PILRB and has been validated for use in Western blot applications, enabling detection and analysis of the PILRB protein in various cell types. PILRB is known to play a role in immune regulation, specifically in inhibiting immune responses and maintaining immune homeostasis. Its involvement in immune modulation makes it a key target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.
By studying the function of PILRB, researchers can gain valuable insights into potential therapeutic strategies for manipulating immune responses in these disease contexts. This PILRB Polyclonal Antibody is an essential tool for immunology and cancer research, allowing for precise detection and analysis of the PILRB protein in a variety of experimental settings. With its high reactivity and specificity for human PILRB, this antibody is a reliable choice for researchers seeking to unravel the complexities of immune regulation and its impact on human health.
Antibody Name:
PILRB Antibody (PACO16869)
Antibody SKU:
PACO16869
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:20-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human PILRB
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16869(PILRB Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs.
Synonyms:
paired immunoglobin-like type 2 receptor beta
UniProt Protein Function:
PILRB: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Membrane protein, integral; Immunoglobulin superfamily
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: integral to plasma membrane
Molecular Function:protein binding
Biological Process: transmembrane receptor protein tyrosine kinase activation (dimerization); transmembrane receptor protein tyrosine kinase signaling pathway
NCBI Summary:
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]
