The PILRB Monoclonal Antibody (PAC016868) is a valuable tool for researchers studying the PILRB protein, a cell surface receptor involved in immune regulation and inflammation. This antibody, generated in mice, is highly specific to human samples and has been validated for use in various applications, including Western blotting.PILRB, also known as paired immunoglobin-like type 2 receptor beta, plays a crucial role in modulating immune responses and maintaining immune homeostasis. By binding to its ligands, PILRB is able to regulate inflammatory pathways and immune cell activation, making it a key target for research in immunology and cancer biology.
The PILRB Monoclonal Antibody enables the detection and analysis of PILRB expression in different cell types, providing valuable insights into its function and potential therapeutic applications. Researchers studying diseases such as cancer, autoimmune disorders, and chronic inflammation will benefit from the use of this antibody in their experiments aimed at understanding the role of PILRB in immune regulation.
Antibody Name:
PILRB Antibody (PACO16868)
Antibody SKU:
PACO16868
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human
Immunogen:
Fusion protein of human PILRB
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: PACO16868(PILRB Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
Background:
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs.
Synonyms:
paired immunoglobin-like type 2 receptor beta
UniProt Protein Function:
PILRB: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Membrane protein, integral; Immunoglobulin superfamily
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: integral to plasma membrane
Molecular Function:protein binding
Biological Process: transmembrane receptor protein tyrosine kinase activation (dimerization); transmembrane receptor protein tyrosine kinase signaling pathway
NCBI Summary:
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]
