PILRA Rabbit Polyclonal Antibody (CAB17292)
- SKU:
- CAB17292
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | PILRA Rabbit Polyclonal Antibody |
SKU: | CAB17292 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-180 of human PILRA (NP_840056.1). |
Sequence: | QPSG STGS GPSY LYGV TQPK HLSA SMGG SVEI PFSF YYPW ELAT APDV RISW RRGH FHRQ SFYS TRPP SIHK DYVN RLFL NWTE GQKS GFLR ISNL QKQD QSVY FCRV ELDT RSSG RQQW QSIE GTKL SITQ GQQR TKAT TPAR EPFQ NTEE PYEN IRNE G |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | FDF03; PILRA |
Positive Sample: | Mouse liver,Rat liver |
Cellular Localization: | extracellular exosome, plasma membrane |
Calculated MW: | 34kDa |
Observed MW: | 45kDa |
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
Purification Method: | Affinity purification |
Gene ID: | 29992 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |