The PILRA Polyclonal Antibody (CAB17292) is a valuable tool for researchers studying PILRA, a cell surface receptor involved in immune regulation and modulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PILRA protein, this antibody enables the detection and analysis of PILRA in a variety of cell types, making it an ideal choice for studies in immunology and cancer research.PILRA, also known as paired immunoglobulin-like type 2 receptor alpha, plays a crucial role in modulating immune responses by regulating the activation of immune cells and inhibiting excessive inflammation.
Its involvement in immune regulation makes it a key target for research into diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the function of PILRA is essential for developing targeted therapies that can manipulate immune responses in these disease settings.In conclusion, the PILRA Polyclonal Antibody (CAB17292) offers researchers a powerful tool for studying the role of PILRA in immune regulation and disease development. Its high reactivity and specificity make it an indispensable resource for investigations into the complex mechanisms of immune system modulation.
Product Name:
PILRA Rabbit Polyclonal Antibody
SKU:
CAB17292
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-180 of human PILRA (NP_840056.1).
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
Purification Method:
Affinity purification
Gene ID:
29992
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PILRA Rabbit pAb (CAB17292) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
