The PIK3R3 Polyclonal Antibody (CAB17112) is a valuable tool for researchers studying the PIK3R3 protein, a regulatory subunit of the PI3K complex involved in cell growth, proliferation, and survival pathways. This antibody, derived from rabbit origins, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PIK3R3, also known as p55γ, is a critical component in the PI3K signaling pathway, which plays a key role in various cellular processes such as growth, metabolism, and migration. Dysregulation of PI3K signaling has been implicated in numerous diseases, including cancer, diabetes, and cardiovascular disorders.
By specifically binding to the PIK3R3 protein, this antibody allows for the detection and analysis of PIK3R3 expression in different cell types, making it an essential tool for researchers studying the mechanisms of PI3K signaling and its implications in disease pathology. Its application in immunology and cancer research makes it a valuable asset in advancing our understanding of PIK3R3 function and potential therapeutic interventions targeting this pathway.
Product Name:
PIK3R3/p55PIK Rabbit Polyclonal Antibody
SKU:
CAB17112
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-388 of human PIK3R3/p55PIK (NP_003620.3).
Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity.
Purification Method:
Affinity purification
Gene ID:
8503
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PIK3R3/p55PIK Rabbit pAb (CAB17112) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
