The PIK3C2G Polyclonal Antibody (PACO07210) is a valuable tool for investigating the function of the PIK3C2G gene, a key player in multiple cellular processes including cell growth, proliferation, and survival. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PIK3C2G, a member of the phosphoinositide 3-kinase (PI3K) family, is involved in the regulation of various signaling pathways that impact cell behavior and function. Its dysregulation has been implicated in a variety of diseases, making it a promising target for research in areas such as cancer, diabetes, and cardiovascular disorders.
By facilitating the detection and analysis of PIK3C2G protein expression, this antibody enables researchers to gain insights into the role of PIK3C2G in normal cellular processes and disease pathogenesis. Its reliability and specificity make it an essential tool for studies aimed at unraveling the complex functions of PIK3C2G and its potential as a therapeutic target.
Antibody Name:
PIK3C2G Antibody (PACO07210)
Antibody SKU:
PACO07210
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the N-terminal region of human PI 3-Kinase C2 γ .
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of A549 using PI 3-Kinase C2 gamma antibody. Secondary antibody was diluted at 1:20000.
PIK3C2G: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis. Belongs to the PI3/PI4-kinase family.Protein type: Kinase, lipid; EC 2.7.1.154; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphateChromosomal Location of Human Ortholog: 12p12Cellular Component: cytosol; phosphoinositide 3-kinase complex; plasma membraneMolecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activityBiological Process: phosphatidylinositol biosynthetic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
