PIK3C2A Polyclonal Antibody (CAB21543)
- SKU:
- CAB21543
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IHC
- IF
- IP
Description
Product Name: | PIK3C2A Polyclonal Antibody |
SKU: | CAB21543 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PIK3C2A (NP_002636.2). |
Sequence: | MAQI SSNS GFKE CPSS HPEP TRAK DVDK EEAL QMEA EALA KLQK DRQV TDNQ RGFE LSSS TRKK AQVY NKQD YDLM VFPE SDSQ KRAL DIDV EKLT QAEL EKLL LDDS FETK KTPV LPVT PILS PSFS AQLY FRPT IQRG QWPP GLPG PSTY ALPS IYPS TYSK QAAF QNGF NPRM PTFP STEP IYLS LPGQ SPYF SYPL |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | CPK; OCSKD; PI3-K-C2A; PI3K-C2alpha; PI3K-C2-alpha; PI3-K-C2(ALPHA); PIK3C2A |
Positive Sample: | SK-OV-3,Hep G2 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Nucleus, clathrin-coated vesicle. |
Calculated MW: | 191kDa |
Observed MW: | Refer to figures |
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
Purification Method: | Affinity purification |
Gene ID: | 5286 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |