The PIK3AP1 Polyclonal Antibody (PACO57232) is a valuable tool for researchers studying the PIK3AP1 protein, which is involved in regulating cellular signaling pathways, particularly those related to immune responses. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the PIK3AP1 protein, this antibody enables the detection and analysis of PIK3AP1 in a variety of cell types, making it ideal for research in immunology and cancer biology.PIK3AP1, also known as PI3K adaptor protein 1, is a key player in the PI3K signaling pathway, which is essential for cell growth, survival, and proliferation.
Dysregulation of this pathway has been implicated in various diseases, including cancer and immune disorders. By studying the function of PIK3AP1, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.The PIK3AP1 Polyclonal Antibody offers researchers a reliable tool for investigating the role of PIK3AP1 in cellular signaling pathways and disease development. Its high specificity and sensitivity make it an excellent choice for studying the function of PIK3AP1 in both normal and pathological conditions, paving the way for advancements in the fields of immunology and cancer research.
Antibody Name:
PIK3AP1 Antibody (PACO57232)
Antibody SKU:
PACO57232
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Phosphoinositide 3-kinase adapter protein 1 protein (293-404AA)
Immunofluorescence staining of A549 cells with PACO57232 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
Synonyms:
Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1), PIK3AP1, BCAP
UniProt Protein Function:
BCAP: an adaptor protein for phosphoinositide-3-kinase. Plays a role in connecting B-cell antigen receptor signaling to phosphoinositide 3-kinase activation.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 10q24.1Cellular Component: cytosol; membrane; plasma membraneBiological Process: positive regulation of phosphoinositide 3-kinase cascade; regulation of inflammatory response; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 7 signaling pathway; toll-like receptor 9 signaling pathway
