The PIH1D3 Polyclonal Antibody (PAC041386) is a valuable tool for researchers studying the PIH1D3 protein, which is involved in various cellular processes such as RNA processing and ribosome biogenesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PIH1D3 is a conserved protein that plays a crucial role in the assembly and function of the conserved R2TP complex, which is involved in the activation and stabilization of various proteins. Research has shown that PIH1D3 is essential for maintaining the integrity of the ribonucleoprotein complex and is implicated in regulating gene expression.
This antibody binds specifically to the PIH1D3 protein, enabling researchers to detect and analyze its expression in different cell types. As a key player in cellular processes, understanding the function and regulation of PIH1D3 has important implications for studying RNA metabolism, protein synthesis, and other essential cellular functions. Its involvement in these processes makes it a valuable target for research in fields such as molecular biology, genetics, and cancer biology.
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO41386 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO41386 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Plays a role in cytoplasmic pre-assembly of axonemal dynein.
Synonyms:
Protein PIH1D3 (PIH1 domain-containing protein 3) (Sarcoma antigen NY-SAR-97), PIH1D3, CXorf41
UniProt Protein Function:
PIH1D3: Plays a role in cytoplasmic pre-assembly of axonemal dynein. {ECO:0000250|UniProtKB:Q3KNI6}. Belongs to the PIH1 family. {ECO:0000305}. Interacts with HSPA1A/B, HSP90AA1 and DNAI2. {ECO:0000250|UniProtKB:Q3KNI6}Chromosomal Location of Human Ortholog: Xq22.3Cellular Component: cytoplasmMolecular Function: chaperone binding; protein bindingBiological Process: sperm motility
