The PIGY Polyclonal Antibody (PACO05552) is a powerful tool for researchers studying the PIGY protein, a crucial component of the glycosylphosphatidylinositol (GPI) anchor biosynthesis pathway. This antibody, raised in rabbits, is highly specific and sensitive for detecting PIGY in human samples, making it an excellent choice for Western blot applications.The PIGY protein is essential for the proper anchoring of a variety of proteins to the cell membrane, including important immune system regulators. Dysregulation of the GPI anchor biosynthesis pathway, including PIGY, has been linked to a range of diseases, including immunodeficiencies and neurological disorders.
By studying PIGY using this antibody, researchers can gain valuable insights into the role of GPI anchors in health and disease.With its high reactivity and specificity, the PIGY Polyclonal Antibody is a valuable tool for investigating the function of PIGY in various cell types and disease models. Researchers in fields such as immunology, biochemistry, and neurobiology can benefit from the reliable performance of this antibody in their studies. Trust the PIGY Polyclonal Antibody for accurate and reproducible results in your research endeavors.
Antibody Name:
PIGY Antibody (PACO05552)
Antibody SKU:
PACO05552
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:20000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from the N-terminal region of human PIG-Y.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
PIGY; Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y; Phosphatidylinositol-glycan biosynthesis class Y protein; PIG-Y
UniProt Protein Function:
PIGY: Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. May act by regulating the catalytic subunit PIGA. Belongs to the PREY family.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Mitochondrial; Endoplasmic reticulumChromosomal Location of Human Ortholog: 4q22.1Cellular Component: endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; plasma membrane; integral to membraneBiological Process: GPI anchor biosynthetic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is part of the GPI-N-acetylglucosaminyltransferase (GIP-GnT) complex which initiates the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is synthesized in the endoplasmic reticulum and serves as an anchor for many surface proteins. Proteins containing GPI anchors can have an important role in cell-cell interactions. The transcript for this gene is bicistronic. The downstream open reading frame encodes this GPI-GnT complex protein, while the upstream open reading frame encodes a protein with unknown function, as represented by GeneID:100996939. [provided by RefSeq, Aug 2012]
